Precision Oncology Alliance

Caris Life Sciences® founded the Precision Oncology Alliance™ (POA) to promote the study and appropriate use of molecular testing in the diagnosis and treatment of cancer.​

Precision Oncology Alliance

The Caris Precision Oncology Alliance™ (POA) convenes the brightest minds in oncology, cancer care, clinical research, and drug development. The vision statement of the POA is to build the best-in-class collaborative research network focusing on precision oncology to identify predictive and prognostic markers that help in improving the outcomes and clinical care of patients with cancer. The POA aims to deliver molecular science solutions to promote clinical trials that cultivate combined clinical-genomic data and collaborative research to advance the science of cancer care. The alliance is comprised of a growing network of leading cancer centers from across the country that demonstrate a commitment to precision medicine and work collaboratively to:

  • Integrate molecular testing where appropriate into cancer care and patient treatment management
  • Collaborate on research studies and clinical trials
  • Track longitudinal clinical outcomes, contribute data, and correlate outcomes with molecular clinical demographic attributes
  • Publish innovative abstracts and manuscripts in top-tier journals promoting academic advancement in molecular profiling and its impact on clinical care

It’s important for oncologists and patients to know that their data is available to them for analysis. Our database of clinical outcomes is populated with anonymized data from POA member institutions and from commercially available data. This continuous feedback loop between finding new biomarkers and interpreting their significance, provides insights for drug developers, which ultimately feeds back into our system and directly helps patients.


The Caris Precision Oncology Alliance™ is focused on collecting the latest scientific developments in genomics in order to help ensure the availability of individualized data to oncologists and patients and to further advance the integration of molecular profiling into all aspects of cancer care .”

Chadi Nabhan, MD, MBA, FACP
Precision Oncology Alliance

Chadi Nabhan, MD | Chairman, Precision Oncology Alliance

In addition to creating a thought leadership network to develop best practices and guidelines for integrating molecular profiling into patient treatment management, POA members:

  • Utilize the Caris Molecular Intelligence® platform to identify therapy options and clinical trial opportunities based on the unique molecular characteristics of a patient’s tumor.
  • Contribute to the Caris database. We are increasingly able to link to their electronic medical records to augment their clinical outcomes data with our molecular data in a user interface that allows analysis of the combined data set.
  • Leverage the network to conduct research and to generate and publish clinical outcomes data.
  • Leverage available data to participate in pharma-sponsored precision oncology research studies and enhance the ability to efficiently conduct investigator-initiated trials.
  • Explore cost-effectiveness studies and analyses leveraging Caris data.
  • Partner with payors and regulatory bodies to establish value-based reimbursement.

POA Leadership

Executive Committee
The Caris Precision Oncology Alliance™ (POA) Executive Committee establishes appropriate molecular testing principles to serve as guidelines for the consistent application of tumor profiling across the oncology community. The Executive Committee facilitates collaborative research studies across the POA and coordinates outcome tracking initiatives to generate and document additional medical evidence for the appropriate use and impact of profiling. The Executive Committee of the POA serves as a resource to Caris leadership helping to drive research strategy and direction.

Chadi Nabhan, MD, MBA, FACP

Precision Oncology Alliance

John L. Marshall, MD

Chief, Division Hematology and Oncology Department of Medicine
Professor of Medicine and Oncology
Georgetown University

Elisabeth Heath, MD

Associate Center Director for Translational Sciences
Karmanos Cancer Institute

Heinz-Josef Lenz, MD, FACP

Associate Director for Clinical Research
USC Norris Comprehensive Cancer Center

Thomas Herzog, MD

Deputy Director
University of Cincinnati Cancer Institute and The Barrett Cancer Center

Wafik El-Deiry, MD, PhD, FACP

Associate Dean for Oncologic Sciences
Brown University

Marcia Cruz-Correa, MD, PhD, AGAF, FASGE

Executive Director
University of Puerto Rico Comprehensive Cancer Center

Ruben Mesa, MD

University of Texas, San Antonio, MD Anderson Center

Sagar Lonial, MD, FACP

Professor and Chair
Department of Hematology and Medical Oncology
Emory University

POA Tumor Groups
The POA Tumor Groups identify leadership opportunities, publications, and develop protocols.

Virginia Kaklamani, MD
Professor of Medicine
University of Texas San Antonio
Central Nervous System
Ashley Sumrall, MD, FACP
Associate Professor
Section Chief, Neuro-oncology
Levine Cancer Institute
Cutaneous Oncology

April Salama, MD
Associate Professor of Medicine
Duke Cancer Institute

Emil Lu, MD, PhD, FACP
Assistant Professor and Medical Director
University of Minnesota

Charles Ryan, MD
Professor of Medicine
University of Minnesota

Global Oncology

Gilberto Lopes, MD
Associate Director of Oncology International
Sylvester Comprehensive Cancer Center at University of Miami

Premal Thaker, MD, MS
Professor of Obstetrics and Gynecology
Director of Gynecological Oncology Clinical Research
Siteman Cancer Center
Head and Neck

Tricia Wise-Draper, MD, PhD
Assistant Professor
University of Cincinnati


Jay Yang, MD
Assistant Professor of Hematology and Oncology Member of the Malignant Hematology Multidisciplinary Team
Karmanos Cancer Institute

Andrew Evens, DO, MSc, FACP
Associate Director for Clinical Services
Director of the Lymphoma Program
Rutgers Cancer Institute of NJ
Saad Z. Usmani, MD
Director, Plasma Cell Disorder Program
Director, Clinical Research in Hematologic Malignancies
Levine Cancer Institute

Sonika Dahiya, MD
Associate Professor
Washington University

Valerie Brown, MD, PhD
Valerie Brown, MD, PhD
Professor, Department of Pediatrics
Division of Hematology and Oncology
Penn State University

Jonathan Trent, MD, PhD
Associate Director for Clinical Research
University of Miami

Stephen Liu, MD
Associate Professor of Medicine
Director of Thoracic Oncology
Georgetown Lombardi Comprehensive Cancer Center

Wafik El-Deiry, MD, PhD, FACP
Associate Dean for Oncology
Brown University

POA Pathology Group


Sonika Dahiya, MD       

Associate Professor
Washington University


Yihong Wang, MD, PhD

Associate Professor of Pathology and Laboratory Medicine 
Brown University

Central Nervous System

Giselle Y. Lopez, MD, PhD     

Assistant Professor
The Preston Tisch Brain Tumor Center at Duke


Thuy Phung, MD, PhD   

Associate Professor of Pathology
University of South Alabama


Evgeny Yakirevich, MD   

Professor of Pathology and Laboratory Medicine
Brown University


Rouba Ali-Fehmi, MD

Professor and Vice Chair Pathology
Wayne State University


       Sam Wei, MD, PhD         

Assistant Professor
Department of Pathology
 Fox Chase Cancer Center


Olga Weinberg, MD

Associate Professor
Director of Fellowships
University of Texas Southwestern

Head & Neck

Rebecca Chernock, MD     

Associate Professor
Pathology & Immunology
Washington University


Andrew E. Rosenberg, MD      

Professor, Vice Chair
Director of Bone and Soft Tissue Pathology
University of Miami

Sanja Dacic, MD, Phd   
Professor of Pathology
University of Pittsburgh Medical Center

David Braxton, MD

Molecular Genetic Pathologist

POA Members

The Caris Precision Oncology Alliance™ consists of leading cancer centers around the world that are committed to precision medicine and work collaboratively to advance the delivery of molecular testing and establish standards of care for profiling solid tumors.

POA Publications

Every day, new discoveries confirm the increasing and important role biomarker analysis and tumor profiling have in personalized cancer care. We contribute to the body of research in oncology to advance the understanding of molecular science and further enable the delivery of precision medicine.

POA Newsletter

The Caris Connection e-newsletter is a quarterly publication for all POA members. Each issue highlights a POA member institution, an interview with a key investigator, and the latest news and events happening throughout our alliance. Members can also find updates on the Caris pipeline, the latest POA publications and abstracts, and register for any one of the many Working Group Sessions that take place throughout the year.
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